AAC Fall Webinar Program

Dentin Caries: Death from within?

October 23rd , 11:00 am-1:00 pm ET


Dr. Alex Mira

FISABIO Foundation, Center for Advanced Research in Public Health, Valencia, Spain

Dr. Alex Mira completed his post-doctoral research in the USA in the field of bacterial genomics and a second post-doc at Uppsala University (Sweden) working on microarray technology and bioinformatics. After returning to Spain he initiated his own research group working on the genomics and metagenomics of oral bacteria. In 2009, he was awarded the “Jaime Ferran” National Award for Research in Microbiology, the Biomedal Award in 2012, the UPSANA Research Award in 2016 and the FIPSE National Award for Health Innovation in 2018, the latter for the discovery of S. dentisani and its development as a probiotic to promote oral health. He is currently the principal investigator of the Oral Microbiome Laboratory at the FISABIO Foundation in Spain.

Dr. Cristina Vidal

University of Iowa USA

Dr. Vidal (DDS, MSc, PhD) is Assistant Professor at the Department of Operative Dentistry, University of Iowa College of Dentistry. Her research focuses on the endogenous mechanisms of degradation of dentin organic components in caries lesions and adhesive interfaces. She has experience in therapies to inhibit dentin degradation by mechanically strengthening the tissue and inhibiting collagen-degrading enzymes. Her research aims to characterize the role of endogenous proteases in caries progression, including tissue degradation and reparative mechanisms, for the further development of novel minimally invasive therapies for the management of dentin caries.

Professor Paul Cooper

University of Otago, New Zealand

Professor Cooper obtained a BSc in Genetics from Leeds University (1992) and received his PhD from the University of Birmingham, UK, in Cancer Sciences (1995). In 2000 he joined the School of Dentistry, University of Birmingham, and became Professor of Oral Biology in 2012. He was the Deputy Director of Research for the Institute of Clinical Sciences. In 2019 he was appointed John Arnaud Bell Professor of Oral Biology at the Faculty of Dentistry, University of Otago, New Zealand. He has published widely in several areas of dental research but has particular focus on pulpal inflammatory disease and its crossover with biomaterials and tissue regeneration. He is the current President of the Pulp Biology Regeneration Group of IADR and has also served as the Mineralized Tissue Group (MINTIG) Chair for the British Society for Oral and Dental Research (BSODR) and as a counselor on the BSODR Management Committee.

Intro and welcoming

This session will present the intricate interactions between the bacteria and the host once caries reaches the dentin, including the responses of the dynamic dentin-pulp complex to bacterial invasion and exogenous or endogenous mechanisms for dentin organic matrix degradation. The definition of the threshold between tissue inflammation and possibilities for regenerative and reparative approaches will also be reviewed.

Exogenous mechanisms and enzymes contributing for dentin caries progression

Understanding caries pathogenesis and the complexity of the caries microbiome - are current therapies effective?

Changes in the oral microbiome as lesions advance: tissue dependent hypothesis

Microbiome composition and metabolic activity in moderate and deep dentin caries

SPEAKER: Dr. Alex Mira

Endogenous mechanisms in caries progression

Role of host-derived enzymes: saliva x dentin x pulp

Activation of endogenous enzymes and their role in organic matrix degradation

Can MMPs and other endogenous enzymes interact with the microbiome to promote caries progression?

What about dentin repair?

SPEAKER: Dr. Cris Vidal

The complexity of dentin-pulp biology in caries: What are the modifying factors and how could a conducive environment for healing be generated?

Similar to other tissues and organs throughout the human body the dentine-pulp complex exhibits an innate ability to repair itself. While low level resolving inflammation can promote healing it is however evident that prolonged bacterial infection, chronic inflammation and the clinical application of certain dental materials, can impede the tooth’s natural repair response. Increasing evidence is now accumulating indicating that signalling of dentine-pulp complex repair events can be induced by the local release of dentine matrix components which promote progenitor and stem cell responses. The ability of materials, such as calcium hydroxide and mineral trioxide aggregate, to release these biostimulatory molecules from the tooth’s tissues is likely important in their beneficial clinical effect. Development of novel biologically-based treatment approaches which are antibacterial and anti-inflammatory, and which facilitate the tooth tissues innate regenerative abilities, will provide improved clinical approaches for restoration of the tooth’s integrity for long term patient benefit.

SPEAKER: Dr. Paul Cooper

Panel Discussion

University of Pennsylvania School of Dental Medicine is an ADA CERP Recognized Provider. ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry.

University of Pennsylvania School of Dental Medicine designates this activity for 2.0 continuing education credits.

The webinar is supported by